www.bionand.es

David Alcántara is a Senior Marie Curie Fellow and invited researcher at Bionand since January 2012. Degree in Chemistry at Málaga University and Ph.D (2008) at Seville University under supervision of Prof. Soledad Penadés and Dr. Jesús Martínez de la Fuente in the Instituto de Investigaciones Químicas (CSIC-US) of Sevilla. His Ph.D thesis research focused on the design and synthesis of magnetic glyconanoparticles and their application as contrast agents for Magnetic Resonance Imaging (MRI). In 2008 founded The All Results Journals, the first Total Open Access journals in Science. In 2008 is hired at Prof. Voisin’s biomedica imaging group (RSMB-CNRS, France). In 2009 got a Fulbright fellowship, to continue research on biomedical sensing with Prof. Josephson at Harvard University (2009-2010). In 2010 obtained a Marie Curie fellowship (International Outgoing) to continue research at Harvard Medical School.

In 2012 is incorporated to INA (Instituto de Nanociencia de Aragon) and Bionand as visiting researcher, in the Nanobiotechnology area. In 2013 Dr. Alcantara obtained a Senior Marie Curie Research Fellowship (FP7) to continue his research

His research interests develops in three main areas:

• Cancer detection and monitoring with nanostructured sensors.
• Magnetic Relaxation Switches for microorganisms detections and other pathogens.
• Smart contrast agents for Magnetic Resonance Imaging (MRI).

Since 2010, is the president of the Society for the Improvement of Science (SACSIS) with more than 200 international researchers volunteers.

Publications of interest

• Hoonsung Cho, David Alcántara, Hushan Yuan, Rahul A Sheth, Howard H Chen, Peng Huang, Sean B Andersson, David E Sosnovik, Umar Mahmood, Lee Josephson
  Fluorochrome-Functionalized Nanoparticles for Imaging DNA in Biological Systems. ACS Nano, 2013, 7 (3), 2032–2041
• David Alcántara, Yanyan Guo, Hushan Yuan, Craig J. Goergen, Howard H. Chen, Hoonsung Cho, David E. Sosnovik and Lee Josephson
  Fluorochrome Functionalized Magnetic Nanoparticles for High Sensitivity Monitoring of PCR by Magnetic Resonance, Angew. Chem. Int. Ed., 2012, in press.
• Chen, S., Alcántara, D., Josephson, L.
  A Magnetofluorescent Nanoparticle for Cell Labeling by Covalently Linking the Drugs Protamine and Feraheme, J Nanosci Nanotechnol., 2011, 11 (4), 3058-64
• Larrosa, Mar; Tomé-Carneiro, Joao; Yañez-Gascón, María; Alcántara, David; Selma, Maria; Beltrán, David; García-Conesa, María-Teresa; Urbán, Cristina; Lucas, Ricardo; Tomas-Barberan, Francisco; Morales, Juan; Espín, Juan Carlos.
  Preventive Oral Treatment with Resveratrol Pro-prodrugs Drastically Reduce Colon Inflammation in Rodents, Journal of Medicinal Chemistry, 2010, 53 (20), 7365-73.
• Ricardo Lucas, Francisco Comelles, David Alcántara, Olivia S. Maldonado, Melanie Curcuroze, Jose Luis Parra and Juan Carlos Morales.
  Surface-active properties of lipophilic antioxidants tyrosol and hydroxytyrosol fatty acid esters: a potential explanation for the nonlinear hypothesis of the antioxidant activity in oil-in-water emulsions, J Agric Food Chem. 2010 Jul 14;58(13):8021-6
• Lucas, Ricardo; Alcántara, David; Morales, Juan C.
  A concise synthesis of glucuronide metabolites of biologically relevant dietary bioactive phenolics: hydroxytyrosol, resveratrol and urolithin-B, J Carb Res, 2009, 344, 1340-1346
• D. Alcántara, J. M. de la Fuente, M. Marradi, M. Garcia-Martin, S. Cerdan, and S. Penadés.
  Paramagnetic Gold Glyconanoparticles as New Contrast Agents for Brain Tumour Imaging: the Sugars Control Relaxivities and in vivo Selectivity”. Chem Comm, 2009, DOI: 10.1039/b900957d
• Martina Fuss, David Alcántara, Jesús M. de la Fuente, Pedro M. Enríquez-Navas, Jesús Angulo, Soledad Penadés, Mónica Luna* and Fernando Briones.
  3D multilayer self-assembling of maltose neoglycoconjugate disulfides on hydrophobic graphite, J. Phys. Chem. B, 2008, 112 (37), 11595–11600.
• Fuss, Martina; Alcántara, David; De La Fuente, Jesús; Luna, Mónica; Briones, Fernando; Penadés, Soledad.
  Supramolecular self-assembled arrangements of maltose glyconanoparticles, Langmuir, 2008, 24, 5124-5128.
• E. Grueso, D. Alcántara, J. Martinez, M. Mancera, S. Penades, F. Sanchez and R. Pradogotor
  A kinetic approach for the study of non-covalent interaction between [Ru(NH3)5pz]2+ and gold nanoparticles” J.Chem.Phys.A, 2007, 111, 9769-9774.
• P.Crespo, M.A.Garcia, E.Fernandez, M.Multigner, D.Alcántara, J.M. de la Fuente, S. Penadés, A.Hernando.
  Fe impurities weaken the ferromagnetic behaviour in Au Nanoparticles, Phys.Rev.Lett., 2006, 97, 17, 177203.

Patents of interest

• J. C. Morales , F. Comelles, JL. Parra Juez, D. Alcántara, R. Lucas, O. Sanchez, M. Curcuroze.
  Fenoles lipofilicos como surfactants antioxidantes. Patent number: P200931214, 2010.
• J. C. Morales , J.C. Espin de Gea, I Medina Mendez, M. Larrosa, D. Alcántara, M.J. Yanez ,F. A. Tomas-Barberam,M.J. Gonzalez, M.S. Lois, R. Lucas, M.V. Selma, J. Tome.
  Preparacion del piceido-butirato y piceido-octanoato y su uso en enfermedades de origen inflamatorio. Patent number: 200931169, 2009.
• David Alcántara, Lee Josephson.
  Nanocompositions for monitoring Polymerase Chain Reactions. Patent number: 29539-0033P03; MGH 21173, 2011.