Laboratory of Precision Medicine in Musculoskeletal and Inflammatory Diseases

 

Research:

Our lab uses a precision medicine approach to uncover mechanisms of disease and develop advanced and personalized therapies for skeletal disorders and inflammation. To reach that goal we use a multidisciplinary approach that includes tissue engineering, biomaterials, genetics, stem cell biology, pharmacology and nanoimaging. Our group has classically studied skeletal dysplasias, discovering a number of new genes, mechanisms and disorders that affect the skeleton. Our main goal is to develop new advanced therapies against bone fragility (Osteogenesis Imperfecta and Osteoporosis), short stature syndromes (achondroplasia) and other super-rare skeletal dysplasias. Our approach has led us to specially study three mechanisms of disease that connect them all: Cellular Stress, Inflammation and Aging expanding our research to other pathologies such as COVID19, osteoarthritis, lung insufficiency, autoimmune diseases, etc.

Two core projects summarize our current research goals:

Molecular cell dysfunction in bone and cartilage disease and advanced therapies targeting specific mechanisms (SKELETAL BIOMEDICINE)

This project is one of the two pillars of our research plan. It proposes the use of novel strategies such as generation of skeletal organoids, Skeletal Stem Cells (as a well-defined cellular product) and precision treatments like an anti-stress drugs as target of a universal mechanism of disease: The Cellular Stress. This project searches deep understanding of multiple signaling pathways that govern skeletal pathology and metabolism to find new targets for precision therapies to bone fragility, cartilage degeneration and rare skeletal syndromes. This project is being performed thanks to the support of the CIBER-BBN, ISCIII (Cell Therapy Network), IBIMA, UMA, Junta de Andalucia and nonprofit foundations like Fundacion AHUCE (Asociacion Huesos de Cristal España).

Therapies targeting cytokine modulatory pathways to treat inflammatory response (INFLAMMATORY PATHOLOGIES)

One of the most relevant mechanisms of disease in human pathology is inflammation. It mediates wide range of cellular responses from regulation of the immune system, to regeneration, aging or chronic effect of genetic mutations. Our group works on cellular stress crosstalk with inflammation. This is specially relevant to COVID19 severity as well as other diseases that mediates with cytokine release syndrome. Our several approaches to anti-inflammatory therapy include from repositioning of orphan drugs to treat severe cases of COVID19 to design of new tissue specific molecules for skeletal pathology treatments.

For more information about Ivan Duran scientific production see: https://orcid.org/0000-0001-6097-0402